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目的 探讨单项抗 Ｈ Ｂｃ阳性的健康者接种乙肝疫苗的免疫特点及其应答反应与白细胞介素２（ Ｉ Ｌ２）的关系。方法 对单项抗 Ｈ Ｂｃ 阳性的健康者按是否接种乙肝疫苗分为实验组和对照组１，乙肝五项标记物（ Ｈ Ｂ Ｖ Ｍ）全阴的健康者为对照组２，应用酶联免疫法动态检测其血清 Ｈ Ｂ Ｖ Ｍ 和 Ｉ Ｌ ２。结果 全程免疫后，实验组，对照组１ 和对照组２ 的抗 Ｈ Ｂｓ 阳转率分别为６３％ （６３／１００）、５７％ （２／３５）和７８３％ （４７／６０）。实验组和对照组２ 的抗 Ｈ Ｂｓ 阳转率无论从性别、年龄和抗体滴度比较均有相似的变化规律（ Ｐ＞ ００５）。两组抗 Ｈ Ｂｓ应答者的血清 Ｉ Ｌ ２ 浓度均明显高于各自免疫前的水平（ Ｐ＜ ００１），也明显高于各自同期无应答者（ Ｐ＜ ００５）；而两组无应答者的 Ｉ Ｌ ２ 水平均较各自免疫前升高不明显（ Ｐ＞ ００５）。结论 对单项抗 Ｈ Ｂｃ 阳性的健康者接种乙肝疫苗，可以达到类似 Ｈ Ｂ Ｖ Ｍ 全阴健康者的免疫效果；而不接种疫苗者很少能获得保护性抗体。体内 Ｉ Ｌ ２ 产生不足，可能是乙肝疫苗免疫失败的原因之一。
Objective To investigate the immunological characteristics of hepatitis B vaccine (HBsAg) and its response to interleukin 2 (IL2) in healthy individuals with anti-HBc positive. Methods A single anti-Hbc-positive healthy group was divided into experimental group and control group according to whether the hepatitis B vaccine was inoculated or not.1, The healthy control group with all five HBV markers (H B V M) was control group 2, Its serum H B V M and I L 2 were detected dynamically. Results After the whole immunization, the positive rate of anti-H Bs in experimental group, control group 1 and control group 2 were 63% (63/100), 57% (2/35) and 783% (47/60) respectively ). The positive rate of anti-H Bs in experimental group and control group 2 had similar changes (P> 005) in terms of sex, age and antibody titer. The levels of serum IL-2 in both groups were significantly higher than those before immunization (P <001) and significantly higher than those in non-responders at the same period (P <005) The level of IL-2 in non-responders was not significantly higher than that before immunization (P> 005). Conclusions Hepatitis B vaccine can be administered to healthy individuals with anti-H Bc status only when they are immunized against Hb V M. However, those who do not receive the vaccine have very few protective antibodies. I L 2 in vivo production deficiencies may be one of the reasons for the failure of hepatitis B vaccine immunization.