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铜绿假单胞菌是一种院内感染的常见致病菌，采用疫苗防治该菌是当前研究的热点领域之一。PcrV蛋白作为一种转运蛋白，是重要的免疫调控靶点，可作为一种有效的疫苗候选分子。本文综述了PcrV蛋白、PcrV抗体、核酸疫苗以及重组鼠伤寒沙门菌疫苗等的研究现状，为新型疫苗研发提供参考。“,”Pseudomonas aeruginosa is one type of pathogens causing nosocomial infections. It recently becomes highlight to control this bacterium by the application of related vaccine. PcrV protein, as a transport protein, is an important target for immune regulation and an effective candidate molecule of vaccine. The review outlines the research of PcrV protein, PcrV antibody, nucleic acid vaccine, and recombinant n Salmonella typhimurium vaccine, in order to provide references for the development of novel vaccine.n