论文部分内容阅读
沙尘污染是城市居民呼吸道感染的主要环境诱因。应用文献法对国内外有关环境与人体微生态群落变化的研究报道进行归纳总结,探寻沙尘暴引起机体细胞的免疫应答、氧化损伤以及细胞免疫功能的变化规律,并与沙尘暴暴发引起的优势致病菌定量、定位的群落变化进行比较分析,揭示沙尘环境下人体微生物群落的变化规律,系统分析环境刺激-人体微生态平衡-还原型辅酶Ⅱ(NADPH)介导产生的活性氧簇(ROS)调控细胞功能的耦合机制,阐明环境因素、微生物群落及宿主与人体微生态免疫调控的关系及其目前的研究现状。为日益严重的沙尘污染引起的流行性地方病研究和预防提供理论依据。
Dust pollution is the main environmental incentive for urban residents with respiratory infections. The literature reports were used to summarize the reports of environmental and human microecological community changes at home and abroad, and explore the changes of immune response, oxidative damage and cellular immune function induced by sandstorm. Quantitative and localized community changes were analyzed and compared to reveal the changing rules of microbial community under dust and dust environment and to systematically analyze the regulation of reactive oxygen species (ROS) mediated by environmental stimuli - human microecology balance - reduced coenzyme Ⅱ (NADPH) The coupling mechanism of cell function, elucidate the relationship between environmental factors, microbial communities and host and human micro-ecological immune regulation and the current research status. Provide a theoretical basis for the research and prevention of epidemic endemic diseases caused by the increasingly serious dust pollution.