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传统细胞生物学的观点认为 :亲水性大分子只能通过经典的胞吞作用才能实现细胞内在化。近几年研究发现一些多肽可能通过一种无耗能、无受体介导的方式穿过真核细胞的质膜 ,这些肽被称为穿膜肽 ;现已有许多关于成功利用穿膜肽将生物大分子转运至多种真核细胞内的报道。目前 ,穿膜肽因其高效无害的细胞穿透功能 ,受到现代细胞生物学、药学、基因治疗及细胞免疫等研究领域的关注
The traditional view of cell biology that: hydrophilic macromolecules can only be through the classical endocytosis in order to achieve cell internalization. In recent years, studies have found that some peptides may pass through the plasma membrane of eukaryotic cells in a non-energy-consuming and receptor-less manner. These peptides are called transmembrane peptides. There are many reports on the successful utilization of transmembrane peptides Transports biological macromolecules into a variety of eukaryotic cells. Currently, transmembrane peptides are of interest in the fields of modern cell biology, pharmacy, gene therapy and cellular immunity due to their innocuous cell-penetrating function