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目的 :探讨叶酸治疗老年H型高血压(HBP)患者时对BP值和血清同型半胱氨酸(HCY)水平的影响。方法 :本次实验对象共计病例数为150例,均为2014年11月~2015年11月间收治的老年H型HBP患者,按照数字双盲分配方法以1:1比例将150例患者分为2组,即对照组(CG组=75例)制定科学的饮食-作息方案,同时给予常规降压治疗;观察组(OG组=75例)在CG组基础上使用叶酸进行治疗,2组患者均持续治疗0.5年,采用血压检测仪和循环酶法实时检测患者BP值、HCY值的变化情况。结果 :治疗前CG组、OG组患者BP值和HCY值差异无统计学意义;6M后两组患者的2种指标均显著改善,CG组HCY值平均下降(1.70±0.33)umol/L,OG组下降(6.22±0.40)umol/L,BP值OG组患者下降幅度同样高于CG组,两组数据对比差异显著。结论 :叶酸药效温和、安全性高,在治疗老年H型高血压时能够更高效的降低患者的BP值和HCY含量,因此值得普及使用。
Objective: To investigate the effects of folic acid on BP and serum homocysteine (HCY) levels in elderly patients with Hypertension (HBP). Methods: A total of 150 cases of H-type HBP were enrolled in this study from November 2014 to November 2015. According to the digital double-blind distribution method, 150 patients were divided into The control group (CG group = 75 cases) was given a scientific diet-rest schedule, meanwhile antihypertensive treatment was given. The observation group (75 cases in the OG group) was treated with folic acid on the basis of CG group. The patients in the two groups Continuous treatment of 0.5 years, using blood pressure detector and circulating enzyme real-time detection of patients with BP, HCY value changes. Results: Before treatment, there was no significant difference between BP and HCY values in CG and OG groups. After 6M, the two indexes of both groups were significantly improved (P <0.05), while the HCY in CG group decreased by (1.70 ± 0.33) umol / L and OG The decrease of group (6.22 ± 0.40) umol / L, BP in OG group was also lower than that in CG group, the difference between the two groups was significant. CONCLUSION: Folic acid has a moderate efficacy and high safety. It can be widely used in the treatment of senile Hypertension to reduce BP and HCY content more efficiently.