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目的 :探讨丙种球蛋白早期大剂量静脉滴注(IVIG)治疗新生儿ABO溶血的临床效果。方法 :选择2012年1月~2015年1月本院儿科治疗的90例ABO溶血患儿进行回顾性分析,其中早期组48例(出生后即进行血清学试验确诊后给予IVIG 2.0g/kg/d,连续3d),常规组42例(出现黄疸症状后,待血清学试验确诊后给予0.4g/kg/d丙种球蛋白静滴治疗),对比两组患儿的治疗效果。结果 :治疗前,早期组和常规组患儿的Hb、TBIL、血尿Cys c测定值、NBNA评分差异均无统计学意义;治疗后,早期组的TBIL、血尿Cys c测定值显著的低于常规组,差异具有统计学意义,早期组的NBNA评分高于常规组,差异具有统计学意义;早期组的退黄时间、光疗时间显著的低于常规组,差异具有统计学意义。结论 :早期IVIG治疗新生儿ABO溶血具有较好的临床效果和安全性。
Objective: To investigate the clinical effect of high dose intravenous infusion of gamma globulin (IVIG) on neonatal ABO hemolysis. Methods: Ninety children with ABO hemolysis undergoing pediatric treatment in our hospital from January 2012 to January 2015 were retrospectively analyzed. Among them, 48 cases in the early group (IVIG 2.0g / kg / d for 3 consecutive days), 42 patients in the routine group (0.4g / kg / d intravenous gamma globulin after diagnosis of jaundice). The therapeutic effect was compared between the two groups. Results: Before treatment, there were no significant differences in Hb, TBIL, Cys c and NBNA scores between the early group and the routine group. After treatment, the values of TBIL and Cys c in the early group were significantly lower than those of the conventional group Group, the difference was statistically significant, early NBNA score higher than the conventional group, the difference was statistically significant; early group of yellowing time, phototherapy time was significantly lower than the conventional group, the difference was statistically significant. Conclusion: Early IVIG treatment of neonatal ABO hemolysis has a good clinical effect and safety.