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70年代Itkin等在治疗哮喘病人时发现,应用能有效杀灭病原菌的抗生素并不能改善病人的症状,而应用对病原菌并不敏感的大环内酯类抗生素三乙酰竹桃霉素(TAO)治疗,患者症状、FEV1均明显改善;1984年日本学者应用小剂量400～600mg/d红霉素(EM)治疗泛细支气管炎(DPB),结果病人死亡率明显下降,由此,人们不断发现和研究了大环内酯类的非抗微生物作用及作用机制,本文就大环内酯类的非抗微生物作用研究及临床应用作一综述。
Itkin and other 70 in the treatment of asthma patients found that the application of antibiotics can effectively kill the pathogen does not improve the patient’s symptoms, and the application of the pathogen is not sensitive to the macrolide antibiotics triacetyltimectin (TAO) treatment , Symptoms of patients, FEV1 were significantly improved; 1984 Japanese scholars using a small dose of 400 ~ 600mg / d erythromycin (EM) treatment of bronchiolitis (DPB), the results of the patient mortality decreased significantly, The non-antimicrobial effect and mechanism of macrolides were studied. In this paper, the non-antimicrobial activity of macrolides and their clinical application were reviewed.