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目的 探讨茶碱在哮喘治疗中的免疫调节作用。方法 观察 10例哮喘患者在每天口服 40 0mg的茶碱缓释片治疗 6周后 ,其血清T淋巴细胞亚群和IgE水平的变化。 结果 茶碱能显著提高哮喘患者外周血中的CD8T淋巴细胞数 (从治疗前的 18 9%± 4 4%提高到治疗后的 2 5 8%±5 9% ,P <0 0 5 )。并有降低哮喘患者外周血中IgE水平的趋势。结论 茶碱具有免疫调节作用 ,为重新评价茶碱在哮喘治疗中的作用提供了依据。
Objective To investigate the immunomodulatory effect of theophylline in the treatment of asthma. Methods The changes of serum T lymphocyte subsets and IgE in 10 asthmatic patients treated with 40 mg of theophylline sustained-release tablets daily for 6 weeks were observed. Results Theophylline significantly increased the number of CD8 T lymphocytes in peripheral blood of asthmatic patients (from 18 9% ± 4 4% before treatment to 25 58% ± 5 9% after treatment, P 0 05). And reduce the level of IgE in the peripheral blood of asthmatic patients. Conclusion Theophylline has an immunomodulatory effect and provides a basis for re-evaluation of theophylline’s role in the treatment of asthma.