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心肌营养素-1是1995年Pennica等从小鼠心脏发育的胚胎干细胞中克隆表达出的一种蛋白质因子。其为白细胞介素-6细胞因子家族的新成员,它可促使心肌细胞肥大,同时也有促使心肌细胞存活的作用。在缺血性心脏病、心肌病及心力衰竭等疾病时CT-1水平均有升高。本文就CT-1在心血管领域的作用及其机理的研究进展作一综述。
Cardiotrophin-1 is a protein factor cloned by Pennica et al. From mouse embryonic stem cells in 1995. It is a new member of the interleukin-6 cytokine family that promotes cardiomyocyte hypertrophy and at the same time plays a role in cardiomyocyte survival. In ischemic heart disease, cardiomyopathy and heart failure and other diseases CT-1 levels have increased. This review summarizes the research progress of CT-1 in the cardiovascular field and its mechanism.