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【目的】研究超重肥胖幼儿瘦素(leptin,LP)水平与体质指数(body mass index,BMI)的关系。【方法】采用卧式身高仪测量儿童身高,电子秤称量体重。利用酶联免疫吸附法(ELISA)测定血清LP水平。采用t检验、Kruskal-Wallis H检验、秩转换的方差分析、Spearman秩相关分析统计数据。【结果】共检查238例(男121例,女117例)健康幼儿,正常组152例,超重组61例,肥胖组25例;三组间血清LP水平比较差异均有统计学意义(P<0.05);幼儿血清LP水平与体质指数(body mass index,BMI)之间有正相关性(rs=0.718,P<0.05);三组间BMI比较差异有统计学意义(P<0.05);三组内男、女童BMI之间比较,差异均无统计学意义(P>0.05)。【结论】随着BMI增加,血清LP水平呈上升趋势,二者之间存在正相关,表明肥胖幼儿可能存在LP抵抗。
【Objective】 To investigate the relationship between leptin (LP) level and body mass index (BMI) in overweight and obesity children. 【Method】 The children’s height was measured by horizontal height meter, and the scales were weighed. Serum LP levels were measured by enzyme-linked immunosorbent assay (ELISA). T test, Kruskal-Wallis H test, analysis of variance of rank conversion and Spearman rank correlation analysis were used. 【Results】 A total of 238 healthy children (121 males and 117 females) were enrolled in this study. There were 152 normal subjects, 61 overweight patients and 25 obesity patients. There were significant differences in serum LP levels between the three groups (P < 0.05). There was a positive correlation between serum LP level and body mass index (BMI) in infants (rs = 0.718, P <0.05). There was significant difference in BMI between the three groups (P <0.05) There was no significant difference in BMI between boys and girls (P> 0.05). 【Conclusion】 With the increase of BMI, the level of serum LP is on the rise. There is a positive correlation between the two, indicating that there may be LP resistance in obese children.