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目的：研究同型半胱氨酸（ＨＣＹ）促进血管平滑肌细胞（ＶＳＭＣ）的增殖及其机制。方法：采用同位素技术测定３ＨＴｄＲ参入和丝裂素活化蛋白激酶（ＭＡＰＫ）活性。结果：ＨＣＹ促进ＶＳＭＣ增殖，同时ＨＣＹ增加ＭＡＰＫ活性，二者均具有剂量效应关系，而且二者之间呈显著正相关。结论：ＨＣＹ促进ＶＳＭＣ增殖，可能是通过增加ＭＡＰＫ活性的途径实现的
AIM: To investigate the effects of homocysteine (HCY) on the proliferation of vascular smooth muscle cells (VSMC) and its mechanism. Methods: 3H-TdR incorporation and mitogen-activated protein kinase (MAPK) activity were measured using isotope techniques. Results: HCY promoted the proliferation of VSMCs, while HCY increased the activity of MAPK, both of which had dose-response relationship, and there was a significant positive correlation between the two. CONCLUSION: HCY can promote the proliferation of VSMC possibly through increasing the activity of MAPK