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在27只隔离灌流颈动脉窦区的麻醉大鼠，观察了腺苷（adenosine，Ado）对颈动脉窦压力感受器反射的影响。所得结果如下：（1）以 Ado（125μmol／L）隔离灌流大鼠左侧颈动脉窦区时，压力感受器机能曲线向左下方移位，曲线最大斜率（PS）由0．37±0．02增至0 55±0．02kPa／KPa（P＜0．001），反射性血压下降幅度（RD）由5．53±0．12增至7．76±0．36KPa；阈压（TP）、平衡压（EP）和饱和压（SP）则分别从8．60±0．27，12．53±0．30和23．69±0．15下降至5．63± 0．11kPa，10．89±0．29KPa和20．18±0．55KPa（P＜0．01－0．001 ）。其中RD，PS和TP的变化呈明显的剂量依赖性。（2）用腺苷选择性 A1受体拮抗剂（8－cyclopentyl－l，3－dipropylianthene，0．134mmol／L）预处理后，Ado的上述反射效应即被阻断。（3）先给予KATP通道阻断剂格列苯脲（glibenclamide．10μmol／L）亦可取消腺苷对压力感受器反射的影响。以上结果表明， Ado对大鼠颈动脉窦压力感受器活动有易化作用，这一作用似与腺苷A1受体介导的KATP通道开放有关。
The effects of adenosine (Ado) on the carotid sinus baroreceptor reflex were observed in 27 anesthetized rats with isolated perfused carotid sinus. The results obtained were as follows: (1) When the left carotid sinus was isolated by Ado (125μmol / L), the baroreceptor shift was shifted to the lower left. The maximum slope (PS) was 0.37 ± 0.02 (RD) increased from 5.53 ± 0.12 to 7.76 ± 0.36KPa; the threshold pressure (TP), The equilibrium pressure (EP) and saturation pressure (SP) decreased from 8.60 ± 0.27, 12.53 ± 0.30 and 23.69 ± 0.15 to 5.63 ± 0.11 kPa and 10.89 ± 0.29KPa and 20.18 ± 0.55KPa (P <0.01-0.001). Among them, the changes of RD, PS and TP were obviously dose-dependent. (2) The above-mentioned reflex effect of Ado was blocked by pretreatment with 8-cyclopentyl-l (3-dipropylianthene, 0.134mmol / L). (3) Glibenclamide (10μmol / L), a KATP channel blocker, can also be used to cancel the effect of adenosine on the baroreflex reflex. These results suggest that Ado may play an important role in the carotid sinus baroreceptor activity in rats, which may be related to the adenosine A1 receptor-mediated KATP channel opening.