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目的：探讨干扰素γ（ＩＦＮγ）对人胰腺癌细胞ＣＤ４４蛋白表达的影响。方法：使用ＣＤ４４ｓ，ＣＤ４４ｖ９，ＣＤ４４ｖ６和ＣＤ４４ｖ４单抗，采用流式细胞分析和免疫组化方法检测ＩＦＮγ作用于人胰腺癌细胞（ＳＷ１９９０）４８ｈ后，ＣＤ４４蛋白表达的变化。结果：ＩＦＮγ作用４８ｈ后，ＳＷ１９９０细胞实验组ＣＤ４４ｓ，ＣＤ４４ｖ９，ＣＤ４４ｖ６和ＣＤ４４ｖ４的表达均较对照组升高，其中ＣＤ４４ｖ６和ＣＤ４４ｖ４表达增加在统计学上有显著意义（Ｐ＜０．０５）。结论：ＩＦＮγ对人胰腺癌细胞ＣＤ４４蛋白的表达有调节作用
Objective: To investigate the effect of interferon γ (IFNγ) on the expression of CD44 protein in human pancreatic cancer cells. Methods: CD44s, CD44v9, CD44v6 and CD44v4 monoclonal antibodies were used to detect the expression of CD44 protein after 48 h of human pancreatic cancer cells (SW1990) treated with IFNγ by flow cytometry and immunohistochemistry. Results: The expression of CD44s, CD44v9, CD44v6 and CD44v4 in SW1990 cells was higher than that in the control group after 48h of IFNγ treatment. The expression of CD44v6 and CD44v4 was significantly increased (P<0.05). Conclusion: IFNγ regulates the expression of human pancreatic cancer CD44 protein