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酸性神经酰胺酶(acid ceramidase,AC)是位于溶酶体内的神经酰胺(ceramide,Cer)代谢酶,能够调节神经酰胺(Cer)/鞘氨醇(sphingosine,Sph)/1-磷酸鞘氨醇(sphingosine1-phosphate,S1P)之间的相互代谢平衡。而Cer和S1P已被公认是调控细胞生长、增殖和死亡的重要信号分子,AC的过量表达,可使S1P水平升高,产生抗细胞凋亡效应。因此,AC有希望成为癌症治疗的全新靶点之一,通过抑制AC活性,诱导肿瘤细胞凋亡,为癌症治疗提供了新思路。本文对近年来AC抑制剂的研究进展进行综述。
Acid ceramidase (AC) is a ceramide (Cer) metabolizing enzyme located in the lysosome and regulates the activity of cer / sphingosine (Sph) / sphingosine-1 -phosphate sphingosine1-phosphate, S1P). Cer and S1P have been recognized as important signaling molecules regulating cell growth, proliferation and death. Over-expression of AC can increase S1P level and produce anti-apoptotic effect. Therefore, AC hopes to become a new target of cancer therapy, which can provide new ideas for the treatment of cancer by inhibiting AC activity and inducing tumor cell apoptosis. This article reviews the progress of AC inhibitors in recent years.