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目的：探讨中医活血化瘀法对慢性肺源性心脏病（肺心病）急性发作期的治疗效果。方法：中西医组４３例患者和单纯西医治疗对照组３９例患者均以吸氧、解痉平喘、抗感染及纠正呼吸衰竭和心力衰竭为基础治疗。中西医组又在辨证分型的基础上加用中药治疗。２组均治疗２～３周；并于治疗前后检测血浆内皮素１（ＥＴ１）水平。结果：中西医组总有效率（９０．６９％）显著优于对照组（７４．３５％），Ｐ＜０．０５。血浆ＥＴ１水平中西医组治疗后为（６９．９±１５．７）ｎｇ／Ｌ，显著低于对照组（７８．３±１３．７）ｎｇ／Ｌ，Ｐ＜０．０１。结论：中医活血化瘀法辨证加减与西医综合治疗对肺心病急性发作期患者可明显提高总有效率、降低血浆ＥＴ１水平，疗效优于单纯西医药治疗
Objective: To investigate the treatment of chronic cor pulmonale (pulmonary heart disease) acute exacerbation by traditional Chinese medicine. Methods: Forty-three patients in the WMD group and 39 patients in the WM group were all treated with oxygen inhalation, antispasmodic and antiasthmatic drugs, anti-infectives and correct respiratory failure and heart failure. Western medicine group in addition to syndrome differentiation based on the use of traditional Chinese medicine. Both groups were treated for 2 to 3 weeks. Plasma endothelin 1 (ET1) levels were measured before and after treatment. Results: The total effective rate (90.69%) in the WM group was significantly higher than that in the control group (74.35%), P <0.05. The level of plasma ET1 in Chinese and Western medicine groups was (69.9 ± 15.7) ng / L after treatment, which was significantly lower than that in control group (78.3 ± 13.7) ng / L, P <0.01. Conclusion: TCM syndrome differentiation plus traditional Chinese medicine combined therapy can significantly improve the total effective rate and reduce the level of plasma ET1 in patients with acute episode of pulmonary heart disease, and the curative effect is superior to that of western medicine alone