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肿瘤抑制因子p53作为基因组的守护者,能通过细胞周期调控和促进细胞凋亡而阻止癌细胞及机体肿瘤的发生,p53还能参与DNA损伤修复、调节机体代谢及调节繁殖生育等功能。除此而外,近年来研究发现,p53能通过促进病毒感染的细胞凋亡而起到抗病毒作用以及p53受IFN的调控和p53作为转录调控因子还能直接转录激活IRF9、IRF5、ISG15和TLR3等抗病毒基因,从而确定了p53在抗病毒反应中起到重要作用。p53可能参与先天性免疫、获得性免疫及炎症反应而起到抗病毒的作用。
As the guardian of the genome, tumor suppressor p53 can prevent the occurrence of cancer cells and tumor by regulating cell cycle and promoting cell apoptosis. P53 is also involved in the repair of DNA damage, the regulation of metabolism and the regulation of reproductive and reproductive functions. In addition, in recent years, it has been found that p53 can play an antiviral role by promoting apoptosis of virus-infected cells as well as that p53 is regulated by IFN and p53 as a transcriptional regulator can directly transactivate IRF9, IRF5, ISG15 and TLR3 And other antiviral genes, thus confirming that p53 plays an important role in antiviral response. p53 may play an antiviral role in innate immunity, adaptive immunity and inflammatory response.