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【目的】探讨畸变产物耳声发射 (DPOAE)早期发现鼻咽癌放疗后耳蜗功能损害的价值。【方法】利用Capella型耳声发射分析仪在放疗前、放疗中、放疗结束时、放疗后 6个月和放疗后 12个月对鼻咽癌患者的 4 0例耳行DPOAE测试 ,观察其不同频率幅值的变化 ,并与纯音测听的骨导听阈比较。【结果】放疗前耳蜗及中耳功能良好者 ,放疗后各时期的畸变产物耳声发射幅值虽有变化 ,但与放疗前 1 0kHz[(9 9± 4 9)dB],2 0kHz[(- 0 7± 8 6 )dB],4 0kHz[(2 9± 6 2 )dB],6 0kHz[(1 4± 7 4 )dB]比较 ,经方差分析 ,无明显统计学意义 (P >0 0 5 ) ,DPOAE的结果与骨导听阈的结果一致。【结论】DPOAE可用于鼻咽癌放疗后内耳损伤的检测 ,具有快速、客观、简便、灵敏及无创等优点。
【Objective】 To investigate the value of distortion product otoacoustic emissions (DPOAE) early detection of nasopharyngeal carcinoma after radiotherapy of cochlear dysfunction. 【Methods】 40 patients with nasopharyngeal carcinoma (DPOAE) were tested for DPOAE by Capella otoacoustic emission analyzer before radiotherapy, during radiotherapy, at the end of radiotherapy, 6 months after radiotherapy, and 12 months after radiotherapy. Frequency amplitude changes, and pure tone audiometry bone conduction threshold comparison. 【Results】 The results showed that although the amplitude of the otoacoustic emissions before and after radiotherapy were significantly different from those before the radiotherapy, the amplitude of the otoacoustic emissions was significantly different from that before radiotherapy (10 ± 10 9 9 ± 4 9 dB, 2 0 kHz [( - 0 7 ± 8 6) dB], 4 0kHz [(2 9 ± 6 2) dB], 6 0kHz [(14 ± 7 4) dB], and there was no significant difference 0 5), the results of DPOAE are consistent with the results of bone conduction threshold. 【Conclusion】 DPOAE can be used to detect the damage of the inner ear of nasopharyngeal carcinoma after radiotherapy. It has the advantages of fast, objective, simple, sensitive and noninvasive.