Neurogenesis versus neurodegeneration: the broken balance in Alzheimer's disease

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Alzheimer\'s disease (AD) is a progressive neurodegenerative disorder, eventually manifesting in severe cognitive dysfunction. Despite the recent proliferation of encouraging preclinical studies and clinical trials, scientific society is still far from a complete consensus regarding the AD etiology and pathogenesis. Accordingly, no approved AD-modifying therapies are currently available. Nevertheless, novel concepts predicated upon the latest discoveries and comprehension of the disease as a multifactorial disorder are paving the road to the successful AD treatment.
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