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钙通道阻滞剂广泛用于治疗各种心血管病,特别是硝苯吡啶向世以来,已成功地用于治疗高血压。近几年来,又相继合成了许多新型的硝苯吡啶同系物,它们构成了钙通道阻滞剂中以硝苯吡啶为代表的一大组化合物。目前在临床试用的有尼群地平(Nitrendipine)、尼索地平(Nisoldipine)、尼卡地平(Nicardipine)、非洛地平(Fclodipine)、尼莫地平(Nimodipine)等。它们都为双氢吡啶衍生物,临床及药理作用基本类同,但又各具特点。特别是尼群地平能干扰体内钙离子的生理功能,包括心肌和平滑肌的兴奋收缩偶联作用。其降压作用持续时间较长,已受到临床重视。由于各种钙通道阻滞剂的血流动力学和左心室功能效应不尽相同,因此观察和检测尼群地平的短期血流动力学很有必要。本文报道应用CFI检测高血压病人在尼群地平一次给药前后的血流动力学和左室功能变化。
Calcium channel blockers are widely used in the treatment of various cardiovascular diseases, especially nifedipine since the world has been successfully used to treat high blood pressure. In recent years, many new types of nifedipine homologs have been synthesized in succession. They constitute a large group of compounds represented by nifedipine in calcium channel blockers. Nitrendipine, Nisoldipine, Nicardipine, Fclodipine, Nimodipine and others currently in clinical trials. They are dihydropyridine derivatives, clinical and pharmacological effects of basic similarities, but each with its own characteristics. In particular, nitrendipine can interfere with the physiological functions of calcium in the body, including the excitation-contraction coupling of myocardium and smooth muscle. Its antihypertensive effect lasts longer and has received clinical attention. Because various calcium channel blockers have different hemodynamic and left ventricular functional effects, it is necessary to observe and measure the short-term hemodynamics of nitrendipine. This article reports the use of CFI detection of hypertensive patients before and after administration of nitrendipine hemodynamics and left ventricular function changes.