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目的：进一步探讨外周血中血小板α颗粒膜蛋白ＧＭＰ—１４０的含量与脑梗塞（ＣＩ）发生、发展的关系。方法：采用双抗夹心放免法检测分析了３２例ＣＩ患者外周血中ＧＭＰ—１４０的含量并与２０例健康人进行比较。结果：ＣＩ患者的血浆ＧＭＰ—１４０的含量较对照组升高（Ｐ＜０．０５），病情重者、梗塞体积大者升高幅度较大。结论：血浆ＧＭＰ—１４０在ＣＩ的发生、发展中起着重要作用，并对病情监测和预后评估有重要的参考价值。
Objective: To further explore the relationship between the content of platelet α-membrane protein GMP-140 in peripheral blood and the occurrence and development of cerebral infarction (CI). Methods: The content of GMP-140 in peripheral blood of 32 CI patients was analyzed by double-antibody sandwich radioimmunoassay and compared with 20 healthy people. Results: The plasma levels of GMP-140 in patients with CI were higher than those in control group (P <0.05). In severe cases, the patients with large infarction volume increased greatly. Conclusion: Plasma GMP-140 plays an important role in the occurrence and development of CI and has important reference value for disease monitoring and prognosis evaluation.