论文部分内容阅读
[目的]探讨动态增强磁共振结合实验室检查对未分化性关节炎(UA)患者病情转归的预测价值.[方法]选取2013 年4月至2017 年4月本院收治的180例UA患者的临床资料,根据随访结果是否进展为风湿关节炎(RA),将其分为 RA组(n=78)和非 RA组(n=71),其余 31 例患者资料不全剔除.所有患者均行动态增强磁共振(MRI)检查和相关实验室指标检查,比较 RA组与非 RA组患者的动态增强 MRI各指标和各相关实验室指标,并分析动态增强 MRI各指标预测UA向RA转归的诊断效能.[结果]两组类风湿因子(RF)阳性所占比例比较,差异无统计学意义(P >0.05).RA 组相对增强(RELENH)、最大增强(MAXENH)、最大相对增强(MAXRELENH)、最大强化斜率(WASHIN)、曲线下面积(AREACURV)、红细胞沉降率(ESR)、C-反应蛋白(CRP)、白细胞介素-6(IL-6)、抗环瓜氨酸肽抗体(ACCP)阳性和抗突变型瓜氨酸波形蛋白抗体(MCV)阳性所占比例比较,差异具有统计学意义(P <0.05).AREACURV 的敏感度最高(96.0%),WASHIN 的 AUC 最高(0.955),CRP特异度最高(89.6%),ACCP 阳性的 AUC最高(0.972),具有最高的诊断效能.[结论]动态增强MRI与实验室相关指标能够较好的预测 UA向 RA转归,可较好的指导早期诊断和治疗.“,”[Objective]To explore the effect of dynamic contrast-enhanced magnetic resonance combined with laboratory tests on the prognosis of patients with undifferentiated arthritis (UA).[Methods]The clinical data of 180 patients with UA admitted in our hospital from April 2013 to April 2017 were selected.According to the fol-low-up results whether RA was developed,they were divided into RA group (n=78)and non-RA group (n=71).The data of the remaining 31 patients were not completely excluded.All patients underwent dynamic contrast enhanced magnetic resonance (MRI)and laboratory tests.The indexes of dynamic enhanced MRI and related labo-ratory indexes were compared between RA group and non-RA group.The diagnostic efficacy of dynamic enhanced MRI in predicting the outcome of UA to RA was analyzed.[Results]There was no significant difference in the pro-portion of (TTP),rheumatoid factor (RF)positive between the two groups at peak time (P >0.05).In the RA group,the relative RELENH,MAXENH,MAXRELENH,WASHIN,AREACURV,ESR,CRP,ACCP posi-tive and MCV positive were significantly different (P<0.05).AREACURV had the highest sensitivity (96.0%), and AUC max.of WASHIN (0.955),CRP specificity max.(89.6%)and AUC of ACCP positive max.(0.972)had the highest diagnostic efficacy.[Conclusion]Dynamic contrast-enhanced MRI and laboratory related indexes can predict the outcome of UA to RA and can guide early diagnosis and treatment.