Mitochondrion-anchoring AIEgen with Large Stokes Shift for Imaging-guided Photodynamic Therapy

• 作 者: FANG Fang GAO Yuting LUO Liang
• 机 构: National Engineering Research Center for Nanomedicine,College of Life Science and Technology,Huazhon
• 出 处: 高等学校化学研究（英文版）
• 发表日期: 2021年1期
• 关键词: Photodynamic therapy Photosensitizer Aggregation-in-duced emission Mitochondria

Photosensitizers that can target and accumulate in mitochon-dria are expected to achieve good therapeutic effects in pho-todynamic therapy,as mitochondria are the energy genera-tion factory in cells.Herein,we designed and synthesized a novel mitochondrion-targeting photosensitizer TPC-Py with aggregation-induced emission characteristics for image-guided photodynamic therapy.TPC-Py possessed an efficient production of 1O2,with a quantum yield of 11.65％,upon mild white light irradiation(6 mW/cm2).TPC-Py exhibited good biocompatibility under dark condition,but showed remarkable cytotoxicity towards human cer-vical carcinoma(HeLa)cells with a half maximal inhibitory concen-tration(IC50)of 3.2 μmol/L when exposed to white light irradia-tion(14.4 J/cm2).In addition,the Stokes shift of TPC-Py was as high as 150 nm,so that it could prevent self-absorption and increase the signal-to-noise ratio of fluorescence imaging.The excellent perfor-mance of TPC-Py makes it a promising candidate in imaging-guided clinical PDT for cancer in the near future.