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目的:研究畅脉舒对实验性动脉粥样硬化(AS)家兔的防治作用机理。方法:采用高胆固醇饲料喂养,建立家兔 AS 模型,以地奥心血康组为对照,随机分为对照组、模型组、地奥心血康组和畅脉舒用药组,各组在实验第14周取血标本测定血脂、血清一氧化氮(NO)、血浆内皮素(ET)、脂质过氧化物(LPO)和超氧化物歧化酶(SOD)等指标。结果:与模型组比较,畅脉舒用药13周后能提高血清 NO、高密度脂蛋白胆固醇(HDL-C)和 SOD 活性(P<0.05或P<0.01),降低 ET、LPO、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)含量和减轻动脉粥样斑块形成(P<0.05或P<0.01);且在降低 ET、LPO、TG、TC、LDL-C 和减轻动脉粥样斑块形成,升高 NO 含量、SOD 活性和 HDL-C 方面均优于地奥心血康(P<0.05或 P<0.01)。结论:畅脉舒具有降低血脂、抗氧化、减少动脉粥样硬化斑块形成的作用。
Objective: To study the preventive and therapeutic mechanism of Chang Mai Shu on rabbits with experimental atherosclerosis (AS). METHODS: A high-cholesterol diet was used to establish a rabbit model of AS. Dioxinxuexinkang group was used as a control and randomly divided into control group, model group, Diaoxinxuekang group and Changmaishu drug group. Blood samples were taken at the 14th week to determine lipid levels in each group. , serum nitric oxide (NO), plasma endothelin (ET), lipid peroxide (LPO) and superoxide dismutase (SOD) and other indicators. Results: Compared with the model group, Changmaishu administration can increase serum NO, high-density lipoprotein cholesterol (HDL-C) and SOD activity (P<0.05 or P<0.01), decrease ET, LPO and triglyceride after 13 weeks. (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) content and atherosclerotic plaque reduction (P<0.05 or P<0.01); and decreased ET, LPO, TG, TC, LDL-C and the reduction of atherosclerotic plaque formation, elevated NO content, SOD activity, and HDL-C were all superior to Diosoxin (P<0.05 or P<0.01). Conclusion: Chang Mai Shu has the effect of lowering blood lipids, antioxidation and reducing the formation of atherosclerotic plaque.