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运用免疫组化染色技术，对５０例鼻咽癌、２４例鼻咽良性病变粘膜进行ｐ５３蛋白表达的测定。结果显示：３８例鼻咽癌ｐ５３蛋白阳性（７６％），３例鼻咽炎性粘膜ｐ５３阳性（１３％），１例鼻咽乳头状瘤ｐ５３阳性。在与临床病理指标的相关分析中发现，ｐ５３阳性程度与肿瘤分化程度有关，分化程度越低，则ｐ５３阳性程度越高，鼻咽癌淋巴结转移与否与ｐ５３蛋白异常表达无关。
The expression of p53 protein in 50 cases of nasopharyngeal carcinoma and 24 cases of nasopharyngeal benign lesion was detected by immunohistochemical staining. The results showed that p53 was positive in 38 cases of nasopharyngeal carcinoma (76%), 3 cases of nasopharyngeal mucosa were positive for p53 (13%) and 1 case was nasopharyngeal papilloma (p53). Correlation analysis showed that the positive rate of p53 was related to the degree of tumor differentiation. The lower the degree of differentiation was, the higher the positive rate of p53 was, and the lymph node metastasis of nasopharyngeal carcinoma was not related to the abnormal expression of p53 protein.