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本文以含磺胺的明胶和蛋白胨小药丸作试验,在甲醛气体中硬化12小时或在甲醛溶液中硬化72小时后,分析两者吸收的甲醛量是相似的,约60毫克/克。分析硬化胶丸中甲醛及磺胺的含量后,贮于真空干燥器中,经20、35及50天后,分别再称重并分析甲醛含量。结果表明,各硬化胶丸中的甲醛含量均保持不变。甲醛气体硬化胶丸失重2.6～3.7%而甲醛溶液硬化胶丸仅失重0.9～1.4%。将上述胶丸在人造胃液肠液中振摇,每隔一定时间分析所释放出的磺胺量。结果表明,贮存期对硬化胶丸释放药物有很大影响。以甲醛溶液新鲜制备的硬化胶丸释放50%药物所需的半数释放时(t~1/_2值)在5～8时之间,经贮存后则大大增加,在5～8小时只能释放15～20%的药物。如以甲醛气体硬化,其
In this paper, sulfated gelatin and peptone pellets were tested. After curing in formaldehyde gas for 12 hours or in formaldehyde solution for 72 hours, the amounts of formaldehyde absorbed by both were similar, about 60 mg / g. After analyzing the contents of formaldehyde and sulfanilamide in the hardened rubber capsules, they were stored in a vacuum drier, and were again weighed and analyzed for formaldehyde content after 20, 35 and 50 days, respectively. The results showed that the content of formaldehyde in the hardened rubber capsules remained unchanged. Formaldehyde gas hardened rubber capsules lose weight 2.6 ~ 3.7% and formaldehyde solution hardened rubber capsules only lose weight 0.9 ~ 1.4%. The above-mentioned capsules in artificial gastric juice shake, at regular intervals to analyze the release of sulfamethoxazole. The results show that the storage period has a great impact on the release of drugs from sclerotherapy capsules. Hyaluronic acid capsules prepared fresh solution of 50% of the time required to release 50% of the drug release (t ~ 1 / _2 value) between 5 to 8 hours after storage greatly increased in only 5 to 8 hours to release 15 ~ 20% of the drug. Such as formaldehyde gas hardening, its