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作者报道了二例惊恐症及一例惊恐症伴有广场恐怖及间发性抑郁。例1、2经阿普唑仑(alprazolam,甲基三唑安定)5mg/日迅速获效,例3用该药治疗亦有效,但因该患者对阿普唑仑产生快速的耐药性,其日用量很快由3mg增至9mg,即使用如此高的剂量仍表现耐药性迹象。作者观察的3例患者在病情改善后,当减少药物的日用剂量(例1由5mg降至1.5mg,例3由9mg降至6mg)或停服(例2),患者分别立即出现严重焦虑、睡眠障碍,烦躁不安及惊恐症发作等戒断反应。经重新给予原来剂量(5mg/日)的阿普唑仑,上述戒断症状很快消失。三例患者均由小剂量
The authors report two cases of panic disorder and one case of panic disorder associated with square horror and depression. Example 1 and 2 through alprazolam (alprazolam, methyl-triazepam) 5mg / day rapid effect, the use of the drug in Example 3 is also effective, but because of the patient’s rapid resistance to alprazolam, Its daily dose quickly increased from 3 mg to 9 mg, which shows signs of drug resistance even at such high doses. Three patients were observed in the condition improved, when the daily dose of drugs to reduce (from 1 to 5mg to 1.5mg, 3 from 9mg to 6mg) or stop taking (Example 2), patients were immediately severe anxiety , Sleep disorders, irritability and seizures and other withdrawal reactions. After re-given the original dose (5mg / day) of alprazolam, the withdrawal symptoms disappear soon. Three patients were treated by small dose