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目的探讨降钙素原和超敏C反应蛋白在新生儿感染性疾病中的应用价值。方法检测我院240例感染性疾病新生儿降钙素原(PCT)和超敏C反应蛋白(hs-CRP),作为观察组,同时选择200例非感染性疾病新生儿作为对照组,比较二者检验结果和PCT、hs-CRP的敏感性和特异性。结果治疗前,观察组PCT和hs-CRP水平均高于对照组(10.38±0.25μg/L vs 0.35±0.29μg/L,45.88±6.66 vs 7.55±0.35,P均<0.05),治疗后再次比较,差异无统计学意义(P>0.05);PCT检测特异性具有较大优势(89.00%),二者联合检测敏感性和特异性更为理想(92.08%,95.00%)。结论联合检测PCT和hs-CRP对新生儿重症感染的诊断具有较高的价值,在治疗过程中,动态监测PCT和hs-CRP水平,有助于观察疗效。
Objective To investigate the value of procalcitonin and high sensitivity C-reactive protein in neonatal infectious diseases. Methods The neonatal procalcitonin (PCT) and hypersensitive C-reactive protein (hs-CRP) were detected in 240 patients with infectious diseases in our hospital. As the observation group, 200 newborns with non-infectious disease were selected as the control group, The test results and PCT, hs-CRP sensitivity and specificity. Results Before treatment, the levels of PCT and hs-CRP in the observation group were significantly higher than those in the control group (10.38 ± 0.25 μg / L vs 0.35 ± 0.29 μg / L, 45.88 ± 6.66 vs 7.55 ± 0.35, P <0.05 respectively) (P> 0.05). The detection specificity of PCT was more superior (89.00%). The sensitivity and specificity of combined detection of the two drugs were more favorable (92.08%, 95.00%). Conclusions The combined detection of PCT and hs-CRP is of high value in the diagnosis of severe neonatal infections. During the treatment, dynamic monitoring of PCT and hs-CRP levels may be helpful for the observation of curative effect.