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目的:观察放疗联合唑来磷酸治疗骨转移瘤的临床效果和不良反应。方法:60例骨转移瘤患者随机分为两组,治疗组30例患者放疗期间同时给予唑来磷酸,每次4mg,4周1次;对照组30例患者仅给予单纯放疗。结果:治疗组和对照组疼痛缓解率分别为96.6%和83.3%(P<0.05),治疗组和对照组生活质量改善(KPS)的有效率分别为93.3%和86.6%(P<0.05)。结论:放疗联合唑莱磷酸治疗骨转移瘤有协同作用,能够提高临床疗效,减少新的转移灶出现可能。
Objective: To observe the clinical effects and adverse reactions of radiotherapy combined with zoledronic acid in the treatment of bone metastases. Methods: Sixty patients with bone metastases were randomly divided into two groups. 30 patients in the treatment group were treated with zoledronic acid 4 mg once daily for 4 weeks and 30 patients in the control group received radiotherapy alone. Results: The pain relief rates of the treatment group and the control group were 96.6% and 83.3% respectively (P <0.05). The effective rates of improvement of the quality of life (KPS) in the treatment group and the control group were 93.3% and 86.6%, respectively (P <0.05). Conclusion: Radiotherapy combined with zoledronic acid has synergistic effect on bone metastases, which can improve the clinical curative effect and reduce the possibility of new metastases.