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吡喹酮(Praziquantel)在浓度大于0.1mM时,可抑制电刺激所致的离体大鼠膈肌的收缩作用。在浓度为0.45mM时,可抑制直接刺激膈肌所致的收缩作用。对有些制备,较低浓度的吡喹酮对间接刺激有兴奋作用。筒箭毒(1μg/ml)与低Ca++(0.4、0.8mM)对吡喹酮表现为协同,而KCl(3～6mM)则表现为拮抗作用。新斯的明(2.5～6μg/ml)对吡喹酮作用无影响。吡喹酮(0.05～0.8mM)可使雏鸡颈二腹肌的张力提高,且可对抗乙酰胆碱(50μg/ml)所致的兴奋作用。实验结果提示:吡喹酮对骨胳肌的抑制除主要作用于神经肌肉接头外,对骨胳肌本身也有直接作用。前者作用可能与乙酰胆碱竞争有关。KCl对吡喹酮的拮抗,提示了KCl对减轻吡喹酮在临床上引起神经肌肉方面的不良反应可能有效。
Praziquantel (Praziquantel) can inhibit the contractile effect of isolated rat diaphragm caused by electrical stimulation at a concentration greater than 0.1 mM. In the concentration of 0.45mM, can inhibit the contractions caused by direct stimulation of the diaphragm. For some preparations, the lower concentration of praziquantel is stimulated by indirect stimuli. Myotubes (1μg / ml) and low Ca ++ (0.4,0.8mM) showed praziquantel synergy, while KCl (3 ~ 6mM) showed antagonism. Neostigmine (2.5-6 μg / ml) had no effect on praziquantel. Praziquantel (0.05 ~ 0.8mM) can increase the tension of the chicken neck duodenum muscle, and can be against the stimulation of acetylcholine (50μg / ml). Experimental results suggest that praziquantel inhibits skeletal muscle in addition to the main role in the neuromuscular junction, the skeletal muscle itself also has a direct effect. The former role may be related to acetylcholine competition. The antagonism of KCl to praziquantel suggests that KCl may be effective in reducing the clinical neuropsychological side effects of praziquantel.