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博莱霉素(BLM)是一族糖肽抗菌素,它们的区别在于末端氨基部分不同。已证实,标记的~(14)C-甲基3-氨基丙基二甲锍氯化物可结合到 BLM A_2的氨基部位。如将 BLM A_2,A_(2-a_,A′(2-b),A′_(2-c),A_5,B_2和 B_4的胺在振荡培养的开始时加到发酵培养基中,即可增加含添加胺 BLM 的产率,除 BLM A_2胺外,它们几乎完全抑制其他天然 BLM 的产生。从培养基中可分离得含 BLM B_2、B_4胺的脱亚胺产物
Bleomycin (BLM) is a family of glycopeptide antibiotics that differ in the terminal amino moiety. It has been demonstrated that the labeled ~ (14) C-methyl 3-aminopropyldimethylsulfonium chloride can bind to the amino moiety of BLM A_2. If the amines of BLM A_2, A_ (2-a_, A ’(2-b), A’_ (2-c), A_5, B_2 and B_4 are added to the fermentation medium at the beginning of shaking culture, Increasing the yields of BLM-containing amine additions, almost completely inhibited the production of other natural BLMs except for the BLM A_2 amine.Demoylimines containing BLM B_2, B_4 amines were isolated from the medium