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日益证实在某些人类的疾病中细菌内毒素所起的作用。在许多疾病中鲎试验阳性与细菌内毒素的其它已知病理生理作用的存在是一致的。日本学者曾报告了许多重要的资料,对鲎试验的评价以及对内毒素血症作用的进一步了解有很大贡献。看来,内毒素能从胃肠道或泌尿道(或有革兰氏阴性细菌存在的其它组织部位)释放而进入周身或门静脉循环中,甚至在无菌血症时,亦能引起病理改变。大多数情况下,当细菌和其释放的内毒素同时存在于循环中时,则血鲎试验可能不出现阳性,但是,当来自组织内或胃肠道中的革兰氏阴性细菌的内毒素进入血循环中时,则血鲎试验却常为阳性。革兰氏阴性细菌脑膜炎患者的脑脊液中,亦常能证实有内毒素。其它体液,如尿和腹水也能查出内毒素。用敏感的阿米巴样细胞溶解产物,细致地进行鲎试验,能有助于革兰氏阴性细菌内毒素血症的诊断和正确地说明临床中的部位,有助于对患者的评价。另外,它也能用于对某些疾病患者的连续观察,在某些情况下,鲎试验可以敏感地提供复发的指标。在细菌培养上出现复发感染之前,就可能成为阳性。
The role of bacterial endotoxins is increasingly proven in some human diseases. The positive test in many diseases is consistent with the existence of other known pathophysiological effects of bacterial endotoxins. Japanese scholars have reported a number of important information on the evaluation of 鲎 test and a greater understanding of the role of endotoxemia can make a significant contribution. It appears that endotoxin can be released from the gastrointestinal tract or urinary tract (or other tissue sites where Gram-negative bacteria are present) into the whole body or into the portal circulation, causing pathological changes even in the absence of bacteremia. In most cases, when a bacterium and its released endotoxin are present in the circulation, the hemagglutination test may not appear positive, however, when endotoxin from Gram-negative bacteria in the tissue or in the gastrointestinal tract enters the blood circulation Medium, then the blood test is often positive. Gram-negative bacterial meningitis in patients with cerebrospinal fluid, and often can confirm endotoxin. Other bodily fluids, such as urine and ascites, also detect endotoxins. Using a sensitive amoebic cell lysate, a detailed pheasant test, can aid in the diagnosis of Gram-negative bacterial endotoxemia and correctly describe the clinical site to aid patient evaluation. In addition, it can also be used for continuous observation of patients with certain diseases, in some cases, 鲎 test can provide sensitive indicators of recurrence. It may become positive before a recurrent infection appears on the bacterial culture.