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肝X受体(LXRs)是核受体超家族的成员,包括两种亚型LXRα(NR1H3)和LXRβ(NR1H2)。LXRs被配体激活后,与类固醇X受体(RXRs)形成异源二聚体,再与其靶基因的LXR调控元件结合,通过调节靶基因的转录,调控机体的代谢和炎症反应。
Liver X receptors (LXRs) are members of the nuclear receptor superfamily and include two subtypes LXRα (NR1H3) and LXRβ (NR1H2). After activated by ligand, LXRs form heterodimers with steroid X receptors (RXRs) and then bind to the LXR regulatory elements of its target genes. By regulating the transcription of target genes, LXRs regulate the metabolism and inflammatory response in the body.