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[目的]建立测定甘草酸二铵含量的瑞利散射法。[方法]在一缩二乙二醇作稳定剂的条件下,甘草酸二铵与四苯基氯化磷发生相互作用,使体系在λ=482.98 nm处的光散射增强,并且增强的散射强度与甘草酸二铵的含量成正比,据此利用四苯基氯化磷为光谱探针瑞利散射法测定甘草酸二铵,同时优化了体系光散射检测的实验参数。[结果]在最佳的实验条件下,对甘草酸二铵测定的线性范围0.21～13.3 mg/L,检出限为0.063 mg/L。[结论方法应用于实际甘草酸二铵注射液样品中甘草酸二铵的测定,结果满意。
[Objective] To establish a Rayleigh scattering method for the determination of diammonium glycyrrhizinate. [Method] The interaction of diammonium glycyrrhizinate and tetraphenylphosphonium chloride under the condition of diethylene glycol as stabilizer stabilizes the light scattering of the system at λ = 482.98 nm, and the enhanced scattering intensity And diammonium glycyrrhizinate is proportional to the content, thus using tetraphenylphosphonium chloride as spectral probe Rayleigh scattering method for the determination of diammonium glycyrrhizinate, while optimizing the system light scattering detection of experimental parameters. [Result] Under the optimal experimental conditions, the linear range of determination of diammonium glycyrrhizinate was 0.21 ~ 13.3 mg / L with the detection limit of 0.063 mg / L. [Conclusion] The method was applied to the determination of diammonium glycyrrhizinate in diammonium glycyrrhizinate injection with satisfactory results.