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晚期妊娠中毒症常伴有激素平衡失调,并表现为胎儿一胎盘系统的激素分泌减少,从而导致早产、宫缩乏力、产褥期病理、宫内缺氧、以及死胎等产科并发症。综合检测血清、尿及羊水中的激素含量,有助于进一步了解妊娠中毒症的病因,并在此基础上制定有效的治疗方案。为此,作者对68例不同程度的妊娠中毒症患者的激素平衡进行了研究并与20例正常孕产妇对照。妊娠末三个月及产时进行尿中雌激素、孕二醇,17羟皮质类固醇的测定,以及血清11羟皮质类固醇、孕酮和17β雌二醇的放免测定。第一产程中经羊膜腔穿刺,测定羊水的E_2及17羟皮质类固醇含量。部分病例检测了新生儿脐血的11羟皮质类固
Late gestational toxicosis is often accompanied by steroid imbalance, and the performance of the fetus-placenta system hormone secretion decreased, leading to premature birth, uterine inertia, puerperal pathology, intrauterine hypoxia, and stillbirth and other obstetric complications. Comprehensive detection of serum, urine and amniotic fluid hormone content, help to further understand the etiology of gestosis, and on this basis to develop effective treatment options. To this end, the author of 68 cases of varying degrees of gestosis in patients with hormone balance study and 20 normal pregnant women control. Determination of urinary estrogen, pregnanediol and 17-hydroxycorticosteroids in the third trimester of pregnancy and during delivery, and radioimmunoassay for serum 11-hydroxycorticosteroids, progesterone and 17β-estradiol. The first stage of labor by amniocentesis, determination of amniotic fluid E_2 and 17 hydroxy corticosteroid content. In some cases, detection of 11 hydroxycorticoids in neonatal cord blood