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目的:探讨射波刀立体定向放疗技术治疗结直肠癌肝转移癌的疗效观察。方法:选择2014年1月至2016年2月我院收治的64例结直肠癌肝转移癌患者为研究对象,按照随机数字表法随机分为对照组(32例)和治疗组(32例),对照组患者给予FOLFOX6全身化疗方案,治疗组患者给予FOLFOX6全身化疗和肝脏病灶立体定向放疗(射波刀)治疗。观察患者的治疗3个月后的近期临床疗效和不良反应,6个月后患者生存率和局部控制率,并评价患者的生活质量。结果:治疗3个月后,治疗组患者的总有效率为78.13%,高于对照组的53.13%,差异有统计学意义(P<0.05);治疗6个月后,治疗组的生存率(96.88%)和局部控制率(87.50%)均高于对照组(81.25%和65.63%),差异有统计学意义(P<0.05);治疗6个月后,治疗组患者的情绪功能、认知功能、角色功能、躯体功能、社会功能评分均高于对照组,差异有统计学意义(P<0.05)。两组患者的不良反应发生率比较差异无统计学意义(P>0.05)。结论:射波刀立体定向放疗技术治疗结直肠癌肝转移癌具有较好的近期临床疗效,可提高患者的生存率和局部控制率,改善患者生活质量,且不良反应发生率低,值得临床推广应用。
Objective: To investigate the curative effect of radiosophagectomy with stereotactic radiotherapy in the treatment of colorectal cancer with liver metastases. Methods: Sixty-four patients with metastatic liver cancer of colorectal cancer who were treated in our hospital from January 2014 to February 2016 were selected and randomly divided into control group (32 cases) and treatment group (32 cases) according to the random number table method. , The control group patients were given FOLFOX6 systemic chemotherapy regimen, the treatment group were given FOLFOX6 systemic chemotherapy and liver lesions stereotactic radiotherapy (cyber knife) treatment. Short-term clinical efficacy and side effects after 3 months of treatment were observed. Patients ’survival rate and local control rate after 6 months were also evaluated. Patients’ quality of life was also evaluated. Results: After 3 months of treatment, the total effective rate of the treatment group was 78.13%, which was higher than that of the control group (53.13%), the difference was statistically significant (P <0.05); After 6 months of treatment, the survival rate 96.88%) and local control rate (87.50%) were higher than the control group (81.25% and 65.63% respectively), the difference was statistically significant (P <0.05); After 6 months of treatment, the emotion function and cognition The scores of function, role, body function and social function were higher than those of the control group (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion: The radiotherapy knife stereotactic radiotherapy technology for the treatment of colorectal cancer with liver metastases has good clinical efficacy, can improve the survival rate and local control rate, improve the quality of life of patients, and the incidence of adverse reactions is low, worthy of clinical promotion application.