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天然产生的CD4+CD25+Treg细胞(nTregs)在维持免疫耐受中的重要作用已得到充分肯定。Forkhead家族转录因子FOXP3被认为对nTreg细胞的发育和功能起关键作用,且为nTreg细胞的一个较特异性的标志物。然而,由于活化的效应性T细胞(Tresp)也上调FOXP3表达。因此,FOXP3仍不能作为nTreg细胞的真正特异性标志物。GARP,一个富含亮氨酸的重复系列的孤独Toll样受体,选择性表达于活化的人类nTreg细胞和nTreg细胞克隆体,但不表达于效应性T细胞,被认为是真正的人类活化的nTreg细胞特异性标志物。另外,GARP能直接结合潜伏相关肽(LAP),诱导潜在的TGF-β转化成活化的TGF-β,从而在nTreg介导的抑制功能中起着一定作用。
The important role of naturally occurring CD4 + CD25 + Treg cells (nTregs) in maintaining immune tolerance has been well established. Forkhead family transcription factor FOXP3 is thought to play a key role in the development and function of nTreg cells and is a more specific marker of nTreg cells. However, FOXP3 expression is also up-regulated due to activated effector T cells (Tresp). Therefore, FOXP3 still can not serve as a true specific marker for nTreg cells. GARP, a leucine-rich, repetitive series of isolated Toll-like receptors, is selectively expressed in activated human nTreg cells and nTreg cell clones but is not expressed in effector T cells and is considered to be truly human activated nTreg cell-specific marker. In addition, GARP binds to Latent Latent Peptide (LAP) directly and induces the conversion of latent TGF-β to activated TGF-β, thereby playing a role in nTreg-mediated suppression.