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用雄性家兔进行实验。预先在麻醉条件下行灭菌手术,结扎肝胆管,安装胆总管套管和十二指肠套管。实验时可将流出的胆汁经十二指肠套管送回小肠腔。实验后将两套管的体外端用硅胶管连通,使胆汁自然流回十二指肠。 本实验观察了家兔在吗啡耐受前后肝胆汁分泌的情况。结果表明,静脉灌注吗啡(1毫克/公斤,10分钟注完),可使家兔肝胆汁分泌量明显减少。一般在开始灌注后10分钟胆汁流量即开始减少,此后继续减少,
Experiment with male rabbits. Sterilization surgery under anesthesia in advance, ligation of the bile duct, the installation of common bile duct and duodenal casing. Experiment can be out of the bile by duodenal casing back to the small intestine cavity. After the experiment, the two sets of tubes were connected to the outside of the body by a silicone tube so that the bile naturally flowed back into the duodenum. The experimental observation of rabbit morphine tolerance before and after the secretion of liver and bile. The results showed that intravenous morphine (1 mg / kg, 10 minutes note), can significantly reduce the secretion of hepatic bile in rabbits. Generally 10 minutes after the start of perfusion that began to reduce the flow of bile, then continue to decrease,