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γδ T cells display unique developmental,distributional,and functional pattes and can rapidly respond to various insults and contribute to diverse diseases.Different subtypes of γδ T cells are produced in the thymus prior to their migration to peripheral tissues.γδ T cells are enriched in the liver and exhibit liver-specific features.Accumulating evidence reveals that γδ T cells play important roles in liver infection,non-alcoholic fatty liver disease,autoimmune hepatitis,liver fibrosis and cirrhosis,and liver cancer and regeneration.In this study,we review the properties of hepatic γδ T cells and summarize the roles of γδ T cells in liver diseases.We believe that determining the properties and functions of γδ T cells in fiver diseases enhances our understanding of the pathogenesis of liver diseases and is useful for the design of novel γδ T cell-based therapeutic regimens for liver diseases.