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目的 观察溴隐亭对大鼠佐剂关节炎的影响。方法 取Wistar雄性大鼠 ,分为三组 ,第一组为对照组 ;第二组单纯给予完全佛氏佐剂 (FCA)皮内注射 ,诱发佐剂关节炎 (AA) ;第三组在给予FCA前三天开始给予溴隐亭灌胃 ,连续 7d ,就各组分别观察AA的发生率 ,右后肢脚容量的变化 ,并对继发病进行评分。结果 第三组与第二组比较 ,不仅AA的发病率明显降低 (2 0 %∶6 0 % ) ,而且关节的炎症反应程度及继发病变的评分在两组间均有显著差异。结论 溴隐亭对大鼠佐剂关节炎的原发及继发病变均有抑制作用 ,为临床类风湿关节炎的治疗提供了新的思路。
Objective To observe the effect of bromocriptine on adjuvant arthritis in rats. Methods Male Wistar rats were divided into three groups, the first group was control group, the second group was given complete Freund’s adjuvant (FCA) intradermally and induced adjuvant arthritis (AA) Bromocriptine was administered intragastrically in the first three days of FCA. The incidence of AA and the change of foot volume in the right hind limb were observed respectively for 7 days in each group. The scores of secondary disease were also scored. Results Compared with the second group, the incidence of AA was significantly lower than that of the second group (20%: 60%). There was a significant difference between the two groups in the degree of inflammation and the grade of secondary lesion. Conclusion Bromocriptine can inhibit the primary and secondary lesions of adjuvant arthritis in rats and provide a new idea for the treatment of clinical rheumatoid arthritis.