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目的分析甲、乙、丙型肝炎及肝硬变患者血清ｓＩＬ－２Ｒ变化的意义。方法采用双抗体夹心间接ＥＬＩＳＡ法检测。结果各型肝炎及肝炎后肝硬变患者血清ｓＩＬ－２Ｒ较正常对照显著增高（Ｐ＜０．０１）。乙型慢性迁延性肝炎（ＣＰＨ）的ｓＩＬ－２Ｒ水平明显低于乙型慢性活动型肝炎（ＣＡＨ）、肝炎后肝硬变（ＨＬＣ）、丙型肝炎（丙肝）和甲型肝炎（甲肝）。甲肝患者ｓＩＬ－２Ｒ水平高于其它各类型肝炎患者并显著高于ＣＡＨ、ＣＰＨ患者（Ｐ＜０．０５），ＣＡＨ、ＨＬＣ、丙肝患者ｓＩＬ－２Ｒ水平三者相互无明显差异（Ｐ＞０．０５）。结论ｓＩＬ－２Ｒ可作为肝炎患者免疫状态的监测指标，并可用于分析肝炎患者的病情变化和预后判断
Objective To analyze the changes of serum sIL-2R in patients with hepatitis A, B, C and cirrhosis. Methods Double antibody sandwich indirect ELISA method was used. Results Serum sIL-2R in patients with various types of hepatitis and post-hepatitis cirrhosis was significantly higher than that in controls (P <0.01). The level of sIL-2R in chronic type 2 chronic persistent hepatitis (CPH) is significantly lower than that in chronic active hepatitis B (C-H), post-hepatitis cirrhosis (HLC), hepatitis C (Hepatitis C) and Hepatitis A (Hepatitis A). The level of sIL-2R in patients with hepatitis A was higher than those in other types of hepatitis and was significantly higher than those in patients with CAH and CPH (P <0.05). There was no significant difference in serum sIL-2R among patients with hepatitis C and hepatitis C (P> 0.05). 05). Conclusion sIL-2R can be used as an indicator of immune status in patients with hepatitis, and can be used to analyze the changes in patients with hepatitis and prognosis