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目的检测阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血浆游离脂肪酸(FFA)水平,探索FFA在OSAHS患者中检测的临床意义。方法确诊OSAHS合并高脂血症患者30例,单纯OSAHS患者30例,单纯高脂血症组30例,健康对照组30例,年龄40~75岁,均为男性,以ELSIA法检测血浆FFA水平,采用2×2析因设计方差分析,检验水准α=0.05,使用SPSS17.0统计软件进行数据分析。结果高脂血症、OSAHS时患者血浆FFA升高,OSAHS并高脂血症者更显著,健康对照组正常。结论 FFA参与了OSAHS患者脂代谢紊乱的发病过程。
Objective To investigate the level of plasma free fatty acid (FFA) in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) and to explore the clinical significance of FFA detection in patients with OSAHS. Methods Thirty patients with OSAHS complicated with hyperlipidemia, 30 patients with OSAHS alone, 30 patients with hyperlipidemia alone, 30 healthy controls and 40-75 years old men were included in this study. Plasma FFA levels were measured by ELSIA , Using 2 × 2 factorial design analysis of variance, test level α = 0.05, using SPSS17.0 statistical software for data analysis. Results Hyperlipidemia, OSAHS patients with elevated plasma FFA, OSAHS and hyperlipidemia were more significant, healthy control group normal. Conclusion FFA is involved in the pathogenesis of lipid metabolism disorder in OSAHS patients.