Synthesis of hexacyclic fused isocoumarin framework through selective domino multicyclizations under

• 作 者: Tariq Mahmood Babar Muhammad Moazzam Naseer Muhammad Khawar Rauf Humayun Pervez Masahiro Ebihara Nasim Hasan Rama
• 机 构: Department of Chemistry,Quaid-i-Azam University,Institute of Chemical Sciences,Organic Chemistry Div
• 出 处: Chinese Chemical Letters
• 发表日期: 2014年09期
• 关键词: fused skeleton convenient mixing centers assembled challenging structurally attr

A novel fused isocoumarin skeleton has been synthesized through selective domino multicyclizations by mixing homothallic acid and 2,3-diphenylacryloyl chloride at 200 8C under catalyst and solvent free reaction conditions.Six fused rings with two stereogenic centers were assembled in a convenient onepot operation in good yield.The resulting hexacyclic fused isocoumarin skeleton and its stereochemistry was fully characterized and unambiguously confirmed by X-ray diffraction analysis.

A novel fused isocoumarin skeleton has been synthesized through selective domino multicyclizations by mixing homothallic acid and 2,3-diphenylacryloyl chloride at 200 8C under catalyst and solvent free reaction conditions. Sax fused rings with two stereogenic centers were assembled in a convenient one pot operation in good yield. The resultant hexacyclic fused isocoumarin skeleton and its stereochemistry was fully characterized and unambiguously confirmed by X-ray diffraction analysis.