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目的分析广东省2010麻疹减毒活疫苗(麻疹疫苗)强化免疫中疑似预防接种异常反应(Adverse Events Following Immunization,AEFI)发生情况,评价麻疹疫苗接种的安全性,为麻疹疫苗强化免疫提供安全性方面的参考。方法通过全国AEFI信息管理系统,收集广东省2010年9月麻疹疫苗强化免疫活动(对象为8月龄至4岁儿童)期间接种麻疹疫苗后报告的AEFI个案,采用描述性流行病学方法分析相关信息。结果广东省2010年麻疹疫苗强化免疫期间接种了557.09万儿童,报告853例AEFI,报告发生率为153.12/100万。报告一般反应467例,报告发生率为83.83/100万,其中发热449例,报告发生率80.60/100万。报告异常反应325例,报告发生率为58.34/100万,其中过敏性皮疹274例,报告发生率49.18/100万,报告热性惊厥9例,报告发病率1.62/100万,报告过敏性紫癜4例,报告发生率0.72/100万。麻疹疫苗的AEFI 72.10%(615/853)发生在接种后1 d内。13例严重AEFI(热性惊厥9例与过敏性紫癜4例)的预后除1例好转,其余均痊愈。结论麻疹疫苗接种后不良反应发生率低,疫苗安全性好。
Objective To analyze the occurrence of suspected immunization (AEFI) in live-attenuated measles vaccine (measles vaccine) 2010 in Guangdong Province and evaluate the safety of measles vaccine in order to provide safety for measles vaccine. The reference. Methods The AEFI cases reported in Guangdong province during the measles vaccine immunization campaign (from August to 4 years old) in September 2010 were collected through the national AEFI information management system and analyzed by descriptive epidemiological method information. Results During the 2010 measles immunization in Guangdong Province, 5.5709 million children were vaccinated and 853 AEFI cases were reported with a reported incidence of 153.12 / 1 million. Report general response 467 cases, the report rate was 83.83 / 100 million, of which 449 cases of fever, the report rate of 80.60 / 100 million. 325 cases of abnormal reaction, the report rate was 58.34 / 100 million, of which 274 cases of allergic rash, the report rate of 49.18 / 1 million, reported 9 cases of febrile seizures, the reported incidence of 1.62 / 1 million, reported allergic purpura 4 For example, the report rate of 0.72 / 1 million. Measles vaccine AEFI 72.10% (615/853) occurred within 1 d after vaccination. Thirteen patients with severe AEFI (9 cases of febrile seizures and 4 cases of allergic purpura) were cured except 1 case. Conclusion The incidence of adverse reactions after measles vaccination is low, and the vaccine is safe.