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目的:探讨黄体酮治疗早期流产的临床效果及对围生儿结局的影响。方法:将2013年1月-2015年1月本院收治的168例早期流产患者按照住院先后顺序分为A组、B组。给予A组患者黄体酮胶丸口服进行治疗,同时给予B组患者黄体酮肌肉注射进行治疗。比较分析两组患者治疗前后血清孕酮水平变化情况及临床治疗效果。将经过治疗后继续妊娠的156例患者作为C组,以同期到本院进行孕期检查的150例无早期流产症状的健康孕妇为D组。比较分析两组研究对象的围生儿结局。结果:治疗后,A组治疗总有效率为86.9%(73/84),B组治疗总有效率为98.8%(83/84),组间比较,差异具有统计学意义(P<0.05);治疗前,A、B两组患者血清孕酮水平比较(P>0.05);治疗后,A、B两组患者血清孕酮水平较治疗前均明显改善(P<0.05),但两组之间比较,差异无统计学意义(P>0.05);C组、D组围生儿结局比较,差异无统计学意义(P>0.05)。结论:黄体酮治疗早期流产有着较好的临床效果,口服与肌肉注射均能获得较好临床效果,且不会对继续妊娠的围生儿造成不利影响。
Objective: To investigate the clinical effect of progesterone in the treatment of early abortion and its effect on perinatal outcome. Methods: From January 2013 to January 2015, 168 cases of early abortion treated in our hospital were divided into group A and group B according to the order of hospitalization. Patients in group A were treated with progesterone capsules orally, and patients in group B were treated with progesterone intramuscular injection. The changes of serum progesterone level before and after treatment and the clinical treatment effect were compared between the two groups. One hundred and fifty-five healthy pregnant women who did not have the symptoms of early miscarriage during the same period were enrolled in the study. Comparative analysis of two groups of subjects perinatal outcome. Results: After treatment, the total effective rate of group A was 86.9% (73/84), while the total effective rate of group B was 98.8% (83/84). The difference was statistically significant (P <0.05). Before treatment, serum progesterone levels in both A and B groups were significantly higher than those before treatment (P> 0.05). After treatment, serum progesterone levels in both groups A and B were significantly improved (P <0.05), but between the two groups There was no significant difference between the two groups (P> 0.05). There was no significant difference in the outcome of perinatal infants between groups C and D (P> 0.05). Conclusion: Progesterone treatment of early abortion has a good clinical effect, oral and intramuscular injection can get better clinical results, and will not adversely affect the perinatal children continue to pregnancy.