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目的研究ＨＢｓＡｇ阴性肝病患者和自然人群中乙肝病毒（ＨＢＶ）携带者。方法采用ＤＮＡＰＣＲ直接法测定急、慢性肝炎，肝硬变和单项ＡＬＴ增高者共２３１例ＨＢｓＡｇ阴性患者中ＨＢＶＤＮＡ，２４０例ＨＢＶ标志阴性的自然人群对照。结果检出率在患者组和对照组分别为３３．７％（７８／２３１）和１１．５％（２８／２４０），Ｐ＜０．０１。单项ＡＬＴ增高组最高，达６６．７％（１０／１５），其他依次为慢肝组（ＣＨ）４１．９％（１３／３１）、肝硬变组（ＬＣ）３０．７％（５２／１６９）和急肝组１８．７％（３／１０）。单项ＡＬＴ增高组与ＬＣ、急肝组有显著差异（Ｐ＜０．０１）。结论在ＨＢｓＡｇ阴性的肝病患者和自然人群中均有ＨＢＶ携带者
Objective To study the carriers of hepatitis B virus (HBV) in patients with HBsAg-negative liver disease and in natural populations. Methods HBVDNA was detected in 231 HBsAg-negative patients with acute and chronic hepatitis, cirrhosis and single ALT by DNAPCR direct method and compared with 240 HBV-negative natural controls. Results The detection rate was 33.7% (78/231) and 11.5% (28/240) respectively in the patient group and the control group, P <0.01. The single ALT group had the highest rate of 66.7% (10/15), followed by 41.9% (13/31) of the CH group and 30.7% (LC) of the LC group (52.7% 169) and acute hepatic injury group (18.7%) (3/10). The single ALT increased group and LC, acute liver group were significantly different (P <0.01). Conclusion There are HBV carriers in HBsAg-negative liver disease patients and in the natural population