肉毒素注射不能改善帕金森病患者的冻结步态

• 作 者: Wieler M. Camicioli R. Jones C.A. Martin W.R.W. 王孝文
• 机 构: Movement Disorders Clinic Glenrose Rehabilitation Hospital 10230 111 Ave. Edmonton Alta. T5G 0B7 Ca
• 出 处: 世界核心医学期刊文摘(神经病学分册)
• 发表日期: 2005年12期
• 关键词: 帕金森病 肉毒素 步态 指标检查 交叉研究 药物治疗 安慰剂 双盲

Freezing of gait (FOG) is common in patients with Parkinson disease (PD) and responds poorly to medical treatment. Botulinum toxin A (BTX-A) injections into calf muscles decreased FOG in previous open-label studies. The authors conducted a randomized double-blind placebo-controlled crossover study of BTX-A vs placebo in 12 subjects with PD and FOG. No significant improvement with BTX-A was found using subjective and objective measures.

Freezing of gait (FOG) is common in patients with Parkinson disease (PD) and responds poorly to medical treatment. Botulinum toxin A (BTX-A) injections into calf muscles decreased FOG in previous open-label studies. The authors conducted a randomized double -blind placebo-controlled crossover study of BTX-A vs placebo in 12 subjects with PD and FOG. No significant improvement with BTX-A was found using subjective and objective measures.