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将中药蒲黄用化学方法提取出四种组份,观察其对培养的猪主动脉内皮细胞产生PGI_2、tPA以及血小板聚集的影响,结果表明含黄酮类的蒲黄组份F.Ⅳ有强烈的刺激内皮细胞产生PGI_2和tPA活性作用,同时还可抑制ADP诱导的血小板聚集。
The traditional Chinese medicine Puhuang was chemically extracted from the four components and its effect on the production of PGI2, tPA and platelet aggregation in the cultured porcine aortic endothelial cells was observed. The results showed that the F.IV containing flavonoids has a strong F.IV. Stimulating endothelial cells to produce PGI 2 and tPA activity can also inhibit ADP-induced platelet aggregation.