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观察并验证基因工程链激酶（ｒ一ＳＫ）对人血凝块的溶化作用及对脑组织毒性作用、分别采用ｒ－ＳＫ（实验组）和生理盐水（０．９％ＮＳ）（对照组）注入人血凝块形成的ＳＤ大鼠脑内血肿腔，观察血肿溶化效果、结果显示：实验组１５例中，７例血肿完全溶化，５例血肿部分溶化，３例血肿未溶化；对照组１４例血肿均未溶化，有显著差异（Ｐ＜０．０１）。病理组织学观察：实验组血肿周围脑组织病理改变轻于对照组、结论：ｒ一ＳＫ对动物模型脑内血肿局部应用有良好的溶化人凝血块作用；而对周围脑组织无毒性作用。
To observe and verify the melting effect of genetically engineered streptokinase (r-SK) on human blood clots and the toxic effects on brain tissue, respectively, r-SK (0.9% NS) and normal saline In the experiment group, 7 cases of hematoma were completely dissolved, 5 cases of hematoma were partially dissolved and 3 cases of hematoma did not dissolve. In control group 14 Cases of hematoma were not dissolved, a significant difference (P <0.01). Histopathological observation: The histopathological changes of the brain tissue around the hematoma in the experimental group were lighter than those in the control group. Conclusion: r-SK had a good effect of dissolving human clot in the intracerebral hematoma of the animal model, and had no toxic effect on the surrounding brain tissue.