慢性病毒性肝病时胃十二指肠病变的研究

• 作 者: 游晶 庄林 马永良
• 机 构: 云南省昆明市第三人民医院消化科
• 出 处: 新消化病学杂志
• 发表日期: 1997年10期
• 关键词: 慢性病毒性肝病 胃十二指肠 内镜检查结果 胃肠疾病 慢性肝炎 肝功能减退 病变发生率 肝炎病毒 消化性溃疡 胃粘膜屏障

目的研究慢性病毒性肝病与胃十二指肠粘膜病变之间的关系以及慢性病毒性肝病时胃十二指肠粘膜病变的发病机制．方法内镜检查患者１２７例，检查前临床诊断为慢性病毒性肝病组４６例（其中男３９例，女７例，年龄４０３岁±１２９岁）和胃肠病组８１例（其中男５３例，女２８例，年龄３９８岁±１３４岁），进行内镜检查结果比较．结果慢性病毒性肝病组和胃肠病组的ＰＵ，ＣＳＧ发生率分别为３９１％，１００％和４３２％，９８８％，无统计学差异（Ｐ＞００５）．慢性病毒性肝病组的ＧＥＶ，ＤＩ，ＥＩ和ＢＲＧ发生率分别为４０３％，６９６％，３０４％和６０９％，胃肠病组为７４％，２８４％，６２％和１２４％，二者间有显著性差异（Ｐ＜００１）．ＧＥＶ检出率在慢性病毒性肝病组中，活动型肝硬变、慢性肝炎重度与慢性肝炎轻中度比较差异显著（分别为６６７％，５３１％和００％，Ｐ＜００１）．结论慢性病毒性肝病时胃十二指肠粘膜病变发生率较高，肝功能减退及肝炎病毒感染等在胃十二指肠粘膜病变的发病中起重要作用．

Objective To study the relationship between chronic viral liver disease and gastroduodenal mucosal lesions and the pathogenesis of gastroduodenal mucosal lesions in chronic viral liver disease. Methods A total of 127 patients undergoing endoscopy were enrolled in this study. 46 patients (39 males and 7 females, aged 403 ± 129 years) and 81 patients with gastrointestinal diseases (including male 53 cases, 28 females, aged 39.8 years ± 13.4 years), endoscopic examination results were compared. Results The incidence of PU and CSG in chronic viral liver disease group and gastrointestinal disease group were 39.1%, 100% and 432%, 988% respectively, with no statistical difference (P> 0.05). The incidences of GEV, DI, EI and BRG in patients with chronic viral hepatitis were 403%, 696%, 304% and 609%, respectively, while those in patients with gastrointestinal disease were 74% and 284% , 62% and 124% respectively, with significant difference (P <001). GEV detection rate in chronic viral liver disease group, active cirrhosis, chronic hepatitis, severe chronic hepatitis and mild to moderate significant difference (66.7%, 53.1% and 0%, P <0 01). Conclusion The incidence of gastroduodenal mucosal lesions in chronic viral liver disease is high, liver dysfunction and hepatitis virus infection play an important role in the pathogenesis of gastroduodenal mucosal lesions.