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目的观察舒丽启能联合康复新和(或)达立通治老年人反流性食管炎(RE)的有效性和安全性。方法217例老年RE患者随机分为四组:舒丽启能组(A组,52例);舒丽启能+康复新液(B组,59例);舒丽启能+达立通组(C组,50例);舒丽启能+康复新液+达立通(D组,56例)。治疗28 d后,观察老年RE患者的消化道症状改善情况及不良反应。计数资料用χ2检验,治疗前后配对资料用t检验,P<0.05为差异有统计学意义。结果 A、B、C、D组治疗后胸骨后疼痛症状减轻的有效率分别为61.54%、67.79%、46.00%、71.43%,治疗后反酸、烧心症状减轻的有效率分别为46.15%、71.18%、62.00%、92.86%,治疗后腹痛、咽部不适感症状明显好转的有效率分别为48.07%、77.98%、48.00%、82.14%。B、D组与A、C组或分别与A、C组比较差异均有统计学意义(均P<0.05)。结论舒丽启能对老年人RE具有良好的疗效。单用舒丽启能适合治疗轻、中度老年RE患者,联合康复新液组成的二联适合治疗较重的老年RE患者,再加上达立通组成的三联治疗老年RE患者最有效,特别适合重型老年RE患者。
Objective To observe the effectiveness and safety of Shuli Kai in combination with Rehabilitation New and / or Darong Tong in treating elderly patients with reflux esophagitis (RE). Methods A total of 217 elderly patients with RE were randomly divided into four groups: Shuliqi group (group A, n = 52), Shuliqi + Kangfuxinye (group B, n = 59) ); Shu Li Kai + new fluid + Daridan (group D, 56 cases). After 28 days of treatment, the improvement of gastrointestinal symptoms and adverse reactions in elderly patients with RE were observed. Count data using χ2 test, paired t-test before and after treatment, P <0.05 for the difference was statistically significant. Results The effective rates of relieving post-sternal pain were 61.54%, 67.79%, 46.00% and 71.43% in groups A, B, C and D, respectively. The effective rates of relieving symptomatic acid reflux and heartburn after treatment were 46.15% and 71.18 %, 62.00%, 92.86%. After treatment, the effective rates of abdominal pain and pharyngeal discomfort were 48.07%, 77.98%, 48.00% and 82.14% respectively. There was significant difference between group B, group D and group A, C or group A and C (all P <0.05). Conclusion Shu Liqi can have good effect on RE RE. Shu Li alone can be used alone for the treatment of mild and moderate elderly patients with RE, combined with rehabilitation of the new composition of the binary combination for the treatment of elderly patients with severe RE, combined with the triadimefon in the treatment of elderly patients with RE RE most effective, especially for heavy Elderly RE patients.